Two important gene targets for potential treatment of mental illnesses

Researchers at Central South University have identified two important gene targets for the treatment of mental illness, "POU3F2" and "DGCR5." This helps reveal the polygenic genetic mechanisms of mental illness or will be applied to future schizophrenia drug development.

These two findings have been published in the international journal Science, the journal Science Translational Medicine.

"The transcription factor POU3F2 regulates the gene co-expression network in brain tissue of patients with mental disorders" mainly studies schizophrenia and bipolar disorder diseases. An important transcription factor gene "POU3F2" has been discovered in the disease-associated gene co-expression network, which plays a central role in affecting the expression changes of multiple downstream genes, and can be used as an important target for future disease mechanisms and drug development. point.

"The relationship between long-chain non-coding RNA (ribonucleic acid) and schizophrenia in the region of copy number variation associated with schizophrenia, long-chain non-coding RNA "DGCR5" on the human chromosome 22q11.2 region, with humans Normal brain development is closely related, and its abnormal expression will cause a series of changes in the expression of schizophrenia-related genes. "DGCR5" is expected to be applied to the treatment of mental illness.