2table+1figure got a 12-point article: DIA proteome detects the relationship between abnormal complement system and mental illness

Less is more: DIA technology, 2table+1figure, got a 12-point Molecular Psychiatry article

Nature's Molecular Psychiatry (IF=11.64) is the top journal in the field of mental illness.

In January 19th, an article entitled " Complement pathway changes at age 12 are associated with psychotic experiences at age 18 in alongitudinal population-based study: evidence for a role of stress " was published, using DIA technology to study complement. The relationship between the system and mental disorders.

Complement pathway changes at age 12 are associated with psychotic experiences at age 18 in a longitudinal population-based study: evidence for a role of stress

IF=11.64

The complement cascade is an important component of the immune system. There is increasing evidence that abnormalities in the complement system are closely related to mental illness. To further demonstrate the relationship between the two, the researchers performed a DIA proteome test on blood samples from the UK avon longitudinal study of parents and children (ALSPAC) cohort, focusing on 29 of the complement-associated proteins. Expression level . The results showed that the expression levels of the six proteins were associated with mental disorders. Using the rat chronic stress model, the results of the study further indicate that chronic stress may cause abnormal complement pathways and is significantly associated with mental disorders. (Editor: If you look further into their gut flora, there may be more discoveries)

For the reason why DIA technology is used for plasma proteomics research, the author gives a description in the article: DIA technology avoids many problems encountered in non-targeted proteomics research, such as the lack of, the original is as follows:

The author takes the principle of “less is more” for the display of the charts and results in the article, 2 table+1 figure, and the full text of Results has only 3 paragraphs:

1 table and 1 figure: Lists the expression levels associated with several complement pathways detected.

Although there are few words, the author has deliberately removed the information of the two samples in order to ensure the rigor of the data. The reason is that the chromatographic information of the sample is not good. The original text is as follows:

As with this platform, the DIA data has strict quality control. The evaluation of the chromatogram is very important, but it is ignored by everyone. (The DIA data of Zhongke New Life evaluates the chromatographic performance from three dimensions and presents the data in In the report).

Although DIA is a relatively new technology, DIA has emerged in more and more high-level research with innovative improvements in coverage, reproducibility, and accuracy. With the arrival of 2019, we will definitely see more and more applications of DIA technology being reported.

Zhongke New Life is not only the first platform to launch DIA services in China, but also the only platform for continuous deep development of DIA. For example, for the most high-frequency clinical research sample, plasma, we have achieved a single sample, no need to remove high-abundance protein, no need to grade, 2h time quantitative 1000+ protein analysis ability , this breakthrough has been widely reported and reported by the large V platform ( For example, Bioart's previous tweet : A new breakthrough in proteomics technology: blood sample DIA, a new high in quantitative protein count ). Subsequent, the same technology upgrades will also be ported to other types of samples, so stay tuned.

Finally, add a force to the teachers who want to send DIA articles:

Spirit Food Food Delivery: Psychiatry Category SCI Journal Popularity Ranking

Note: The above data is MedSci real-time information, dynamic changes, only for scientific research, not for any commercial use.